ICD-10-CM Code D81: Combined immunodeficiencies and Related Diagnosis Codes.


The ICD-10-CM (the International Classification of Diseases, Tenth Revision, Clinical Modification) is a standardized coding system used when classifying diseases and medical conditions. Healthcare providers report these codes on Medical claims when diagnosing patient care.

Explore ICD-10-CM codes, organized by chapters based on body systems and medical conditions, as outlined in the International Classification of Diseases, Tenth Revision, Clinical Modification.

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A categorized list of ICD-10-CM codes organized by chapters based on body systems or medical conditions, according to the International Classification of Diseases, Tenth Revision, Clinical Modification.

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  • D81 - Combined immunodeficiencies
    • D81.0 - Severe combined immunodeficiency [SCID] with reticular dysgenesis
    • D81.1 - Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
    • D81.2 - Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
    • D81.3 - Adenosine deaminase [ADA] deficiency
      • D81.30 - Adenosine deaminase deficiency, unspecified
      • D81.31 - Severe combined immunodeficiency due to adenosine deaminase deficiency
      • D81.32 - Adenosine deaminase 2 deficiency
      • D81.39 - Other adenosine deaminase deficiency
    • D81.4 - Nezelof's syndrome
    • D81.5 - Purine nucleoside phosphorylase [PNP] deficiency
    • D81.6 - Major histocompatibility complex class I deficiency
    • D81.7 - Major histocompatibility complex class II deficiency
    • D81.8 - Other combined immunodeficiencies
      • D81.81 - Biotin-dependent carboxylase deficiency
        • D81.810 - Biotinidase deficiency
        • D81.818 - Other biotin-dependent carboxylase deficiency
        • D81.819 - Biotin-dependent carboxylase deficiency, unspecified
      • D81.82 - Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
      • D81.89 - Other combined immunodeficiencies
    • D81.9 - Combined immunodeficiency, unspecified

Note: The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes are developed and maintained by the Centers for Disease Control and Prevention (CDC). CDC's National Center for Health Statistics (NCHS) is responsible for the clinical modification of ICD-10 for use in the United States. The World Health Organization (WHO), which owns and publishes ICD-10, authorized NCHS to develop ICD-10-CM. All modifications to ICD-10 must conform to WHO's established ICD structure and conventions. All rights are reserved by the respective entities.